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Characterization of OAS1– RNA complex by Dynamic light scattering (DLS) (CAT#: STEM-MB-0541-WXH)
Introduction
Oligoadenylate synthetase (OAS) proteins are cellular, double-stranded RNA (dsRNA) sensors that function as part of the innate immune response to virus infections. In the human genome, the OAS family consists of one copy each of the OAS1, OAS2, OAS3 and OASL genes.
Principle
Dynamic Light Scattering (DLS) is an established and precise measurement technique for characterizing particle sizes in suspensions and emulsions. It is based on the Brownian motion of particles - this states that smaller particles move faster, while larger ones move slower in a liquid. The light scattered by particles contains information on the diffusion speed and thus on the size distribution.
The Dynamic Light Scattering (DLS) technique measures motion optically by recording the scattered light signal at a fixed angle. The particles are illuminated with a monochromatic, coherent light source (laser) and the light scattered by the particles is recorded.
The Dynamic Light Scattering (DLS) technique measures motion optically by recording the scattered light signal at a fixed angle. The particles are illuminated with a monochromatic, coherent light source (laser) and the light scattered by the particles is recorded.
Applications
DLS is used to characterize the size of various particles including proteins, polymers, micelles, Protein cages and virus-like particles, vesicles, carbohydrates, nanoparticles, biological cells, and gels.
Procedure
1. Sample preparation
2. Measurement by DLS instrument
3. Data analysis
2. Measurement by DLS instrument
3. Data analysis
Materials
• Dynamic Light Scattering (DLS) instruments (Photon Correlation Spectroscopy or Quasi-Elastic Light Scattering instruments)
• Dynamic Light Scattering Detector
• Dynamic Light Scattering Detector
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