Dermatology Animal Model

Skin accounts for 6%-16% of total body weight and is the heaviest organ in the human body. The skin is in direct contact with the external environment, can feel the external environment of cold, heat, pain, and pressure, and at the same time has an important barrier function, can avoid the loss of body fluids evaporation, and defense against the invasion of external harmful substances. In addition, the skin also has the function of regulating body temperature and excreting waste. The epidermis of the skin is comprised of multilayered and stratified epithelial cells that undergo life-long self-renewal through a tightly regulated balance of cell proliferation and terminal differentiation. Disruption of this balance represents a central process of a myriad of skin diseases.