Analysis of Clusterin (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0110-LGZ)

Introduction

Clusterin is a common heterodimer sulfated glycoprotein, whose gene is located in human chromosome 8p21, contains 449 amino acids, and has a relative molecular mass (Mr) of 75,000 ~ 80,000. It mainly exists in the cytoplasm and is secreted into the intracellular environment. Due to different shear translation of CLU mRNA, two variants of sClusterin (sCLU) and nClusterin (nCLU) are formed, which play the role of anti-apoptosis and promoting apoptosis, respectively. In physiological conditions, CLU is mainly involved in the biological processes such as lipid transport, tissue reconstruction, cell-stroma interaction and cell apoptosis. Numerous studies in recent years have shown that CLU plays an important oncogene role in the occurrence and development of various malignant tumors such as renal cell carcinoma, ovarian cancer, breast cancer and prostate cancer.