IL-8 Detection (CAT#: STEM-MB-0277-WXH)

Introduction

IL-8 is a multi-source cytokine that can be produced by monocytes, macrophages, neutrophils, fibroblasts, epithelial cells, T cells, chondrocytes, vascular endothelial cells, liver cells, etc. The main activity is to attract and activate neutrophils, further aggravate the local inflammatory response, and cause the patient's condition to worsen. Recent studies have shown that the increase in IL-8 concentration is often the pathological basis for tissue damage in certain inflammatory diseases, and it is usually the key link that leads to the development of certain diseases. The signal of IL-8 in tumor cells may increase the tumorigenicity, metastasis, invasiveness and viability of the cells. In addition, it can induce glomerular mesangial cells (GMC) to produce extracellular matrix components such as collagen fibers III, IV, and laminin.