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ROCK Signaling Pathway Assay (CAT#: STEM-MB-0313-WXH)
Introduction
Rho-associated kinase (ROCK) is currently the most detailed functional study of Rho downstream target effect molecules. The ROCK signal pathway is a ubiquitous pathway in the central nervous system, and it is an important way to mediate inhibitory signals and block the regeneration of central nerve cells. The ROCK signaling pathway induces cytoskeletal reorganization, cell migration and stress fiber formation, and has various physiological functions such as endothelial permeability, tissue contraction and growth.
Principle
The ROCK signal path includes:
Inhibitory proteins: such as myelin associated glycoprotein (MAG), neuronal growth inhibitor (including Nogo-A, Nogo-B and Nogo-C) and oligodendrocytes Myelin glycoprotein (OMgp).
Receptors that can bind to the inhibitory protein: such as Nogo receptor (NgR), paired immunoglobulin-like receptor B (PirB), p75 neurotrophic receptor (p75 neurotrophic receptor, p75NTR).
Rho factor.
ROCK and ROCK effector molecules.
Inhibitory proteins: such as myelin associated glycoprotein (MAG), neuronal growth inhibitor (including Nogo-A, Nogo-B and Nogo-C) and oligodendrocytes Myelin glycoprotein (OMgp).
Receptors that can bind to the inhibitory protein: such as Nogo receptor (NgR), paired immunoglobulin-like receptor B (PirB), p75 neurotrophic receptor (p75 neurotrophic receptor, p75NTR).
Rho factor.
ROCK and ROCK effector molecules.
Applications
Study the impact of each clinical virus on the ROCK signaling pathway
Research on the regulatory mechanism of ROCK signaling pathway in medicine
Study the effects of drugs or therapies on the ROCK signaling pathway
Research on the regulatory mechanism of ROCK signaling pathway in medicine
Study the effects of drugs or therapies on the ROCK signaling pathway
Procedure
• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology
Notes
Detectable targets: MSK2, SLP76, p38MAPK, MYD88, Rac1, TLR4, ATG16, WIPi2, LC3I, PROLC3, ULK, FIP200, TRIF, VPS34, UYRAG, NFκB, RIG-1, p50, Vav, IRF9, AMBRA1, p38, RIP1, TRAF5, Histone-H3, IRF5, MEK3, mTOR, SH2, TRAF6, ATG3, IRS1, MEK6, PKR, ISRE, TRAM, ISGF3, IRS2, MSK1, p65, Tak1, TBK1
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Wide range of applications
For various laboratory needs
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