Determination of Melting Point of Pyrazine Derivatives of Pentacyclic Triterpenoids by Open Capillary Method (CAT#: STEM-PPA-0096-YJL)

Introduction

Compounds containing N-heterocyclic moieties are a class of privileged compounds that have found numerous applications as pharmaceuticals. Pyrazines are important components of aroma fragrances Citation1, potential pharmacophore of a large number of biologically active substances, and widely used as agrochemicals. For example, methoxy pyrazines are relevant components of aromas of many fruits, vegetables, and wines; methyl phenyl derivatives of dihydropyrazines inhibit the growth of Echerichia coli by generating hydroxyl and carbene-centered radicals that cause DNA strand breakage; and alkylpyrazines have been recognized as flavor components in foods, as pheromones in various insect species, and as versatile synthetic intermediates. Pyrazine derivatives are known for use as relaxing cardiovascular and uterine smooth muscle, anti-thrombotic, anti-aggregation, COX-2 inhibiting, and analgesic effects.