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Determination of Melting Point of Some Trasition Metail Complexes With Hyadrazone Schif Bases by Open Capillary Method (CAT#: STEM-PPA-0104-YJL)
Introduction
Metal complexes is one of the most important field due to its versatile application. Certain metal complexes are used in Industries, for synthesis, It work as catalyst, they have some application in Agriculture. Particularly hydrazine metal complexes are bio-active compound and can used as antitubercular, antimicrobial Antifungal , anticancer, Anticonvconvulasant and antiinflamatori activity. Particularly, the antibacterial and antifungal properties of hydrazone and their complexes with some transition metal ion is reported in letarature. The chelating agent like hydrazine contain C=N linkage is essential for biological activity. Several azomethazines were reported to possess remarkable antibacterial, antifungal, anticancer active.
Principle
Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
Applications
Chemical industry; Cosmetic/pharmaceutical industry
Procedure
1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
Materials
• Sample Type: crystalline compounds
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