Analysis of Polymer Nanoparticles in Blood Plasma by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0715-WXH)

Introduction

A successful drug delivery system must overcome complex biological barriers. For particles injected into the blood, one of the first and most critical barriers pertains to blood stability to circulate through the human body. To effectively design drug delivery vehicles, interactions between the particles and blood, as well as the aggregation behavior, must be understood. Particle size and aggregation in blood plasma can be analyzed using a commercially available nanoparticle tracking analysis (NTA) system.

Add to Cart Please Inquire

Principle Applications Procedure Materials Notes Related Products

Principle

Nanoparticle tracking analysis (NTA) is a method for visualizing and analyzing particles in liquids that relates the rate of Brownian motion to particle size. The rate of movement is related only to the viscosity and temperature of the liquid; it is not influenced by particle density or refractive index. NTA allows the determination of a size distribution profile of small particles with a diameter of approximately 10-1000 nanometers (nm) in liquid suspension.

Applications

NTA has been used by commercial, academic, and government laboratories working with nanoparticle toxicology, drug delivery, exosomes, microvesicles, bacterial membrane vesicles, and other small biological particles, virology and vaccine production, ecotoxicology, protein aggregation, orthopedic implants, inks and pigments, and nanobubbles.

Procedure

1. Sample preparation
2. Nanoparticle Tracking Analysis
3. NTA Data Processing, Display, and Interpretation

Materials

• Nanoparticle Tracking Analysis (NTA) instrument
• NanoSight instrument
• Nanoparticle Analyzer

Other recommended products

Analysis of micelles by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0730-WXH)
Analysis of Extracellular Vesicles by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0714-WXH)
Investigation of Nanodiamonds intracellular transport by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0745-WXH)
Analysis of Probe Transport in Porous Media by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0736-WXH)
Study of polymeric nanoparticle-macrophage interactions by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0720-WXH)
Biomaterials Characterization by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0726-WXH)
Sizing and phenotyping of cellular vesicles by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0706-WXH)
Investigation of Magnetic NPs intracellular transport by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0744-WXH)