Study of the mechanical responses of proteins by Magnetic tweezers (MT) (CAT#: STEM-MB-1241-WXH)

Introduction

Many proteins are subject to mechanical stretching, and an increasing body of evidence has shown that many of these force-bearing proteins play crucial roles in regulating various processes involved in tissue development and maintenance. It is now known that the functions of these force-bearing proteins critically depend on their conformational changes in response to force, which in turn affects their interactions with binding partners. For example, it has been shown<br />that force applied to talin and α-catenin can cause unfolding of the domains inside these molecules, exposing vinculin binding sites for high-affinity