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Determination of Melting Point of New Series of s-Triazines Derived with Quinolines by Open Capillary Method (CAT#: STEM-PPA-0091-YJL)
Introduction
Nitrogen containing heterocycles play an important role, not only for life science industry but also in many other industrial fields related to special and fine chemistry. Among them 1,3,5-triazines represent a widely used lead structure with multitude of interesting applications in numerous fields Several derivatives of s-triazine show antibacterial , mantimicrobial, and herbicidal activities. In addition, quinolines have also been employed in the study of bioorganic and bioorganometallic processes. Benzotriazole (BT) is an anticorrosive agent well known for its use in antifreeze fluids. Benzotriazole derivatives also are pharmaceutically important.
Principle
Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
Applications
Chemical industry; Cosmetic/pharmaceutical industry
Procedure
1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
Materials
• Sample Type: crystalline compounds
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