Necroptosis Analysis (CAT#: STEM-CBT-0014-WXH)

Introduction

Necroptosis is a vertebrate-specific programmed necrosis or inflammatory cell death, which is a process of cell self-destruction triggered by phosphorylation of MLKL mediated by RIP1 and RIP3 kinases when apoptosis is blocked. Necroptosis not only contributes to the clearance of pathogens, but also contributes to disease pathogenesis, characterized by early loss of plasma membrane integrity, leakage of cellular contents, and swelling of organelles. Cells dying by necroptosis lack the typical features of apoptosis, but the exact mechanism is not fully understood.