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Anoikis (Suspension-induced apoptosis) is a special form of programmed cell death induced by cells losing contact with the extracellular matrix (ECM) and other cells. Anoikis is indispensable for maintaining the stability of body tissues. Its main function is to prevent abnormal cell growth or cell adhesion to abnormal ECM. It plays an important role in body development, tissue homeostasis, disease occurrence, and tumor metastasis.
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