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Pulmonary hypertension (PH) is a disease characterized by vascular proliferation and remodeling of small pulmonary arteries. Vascular proliferation and remodeling of the small pulmonary arteries lead to a progressive increase in pulmonary vascular resistance, eventually leading to right heart failure and death. The experimental animals used in the study of pulmonary hypertension include rats, dogs, sheep, cattle, and pigs.
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