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Liver Fibrosis Animal Model (CAT#: STEM-AE-0059-WXH)

Introduction

Hepatic fibrosis refers to the diffuse excessive deposition and abnormal distribution of extracellular matrix such as collagen and proteoglycan after liver cells are repeatedly destroyed during the development of chronic liver diseases. The further development of liver fibrosis can cause structural disorder of the liver, nodular regeneration of liver cells, and formation of pseudolobular structure, that is, liver cirrhosis. Common diseases that cause liver fibrosis include viral hepatitis, alcoholic liver disease, nonalcoholic fatty liver disease, cholestasis, autoimmune liver disease, etc.




Applications

• Research on the mechanism of liver fibrosis.
• Drug screening and curative effect evaluation related to liver fibrosis.
Comparative medical research.

Procedure

1. The method of injecting ethanol into the stomach of rats continuously for 24 weeks while feeding solid feed.
2. Induction of cholestasis: after anesthesia, the common bile duct is ligated and cut off, and the distal end is ligated, and relevant fibrosis indicators can be detected in about 4 weeks.
3. Induction by toxic substances (CCL4, DMN, TAA).
4. Nutritional liver fibrosis: high-fat and high-protein diet.

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