IL-26 Detection (CAT#: STEM-MB-0293-WXH)

Name: IL-26 Detection
SKU: STEM-MB-0293-WXH
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Introduction

IL-26, a member of the IL-10 family produced by memory T cells, monocytes, and NK cells, is expressed at low levels in normal humans. But it is overexpressed in HSV-transformed human T cells, and in rheumatoid arthritis patients, IL-26 is produced primarily by synovial cells. It is highly expressed in the skin, testes, pancreas, heart, placenta, salivary glands, and prostate, but is expressed at low levels in the kidneys, liver, colon, and small intestine. It plays a pro-inflammatory role in rheumatoid arthritis and a role in antitumorigenesis.

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Principle Applications Procedure Notes

Principle

The active receptor complex of IL-26 is a dimer composed of IL-20R1 and IL-10R2, both class II cytokine receptors, with IL-20R1 expressed mainly in non-hematopoietic cells, especially epithelial cells, but not in lymphocytes, whereas IL-10R2 is widely expressed in various tissues. IL-20R1 is the main ligand-binding chain, which associates with Jak1, and the ligand checkpoint causes the initiation of a signal transduction cascade. il-10r2 associates with tyrosine protein kinase 2 (Tyk2), and the receptor-associated Jaks cross-activate and phosphorylate IL-20R1 intracellular domain, which activates STAT1 and STAT3.

Applications

IL-26 has been associated with inflammatory bowel disease and can participate in processes that regulate inflammation and immune responses.
IL-26 effectively promotes the recruitment of neutrophils to the focus of infection and exerted a bactericidal effect.