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TCR Pathway Assay (CAT#: STEM-MB-0340-WXH)
Introduction
TCR (T cell receptor) is a T cell surface receptor, responsible for recognizing the specificity presented by major histocompatibility complex (MHC) on the surface of antigen presenting cell (APC) Sexual antigen peptide, forming TCR-pMHCcomplex (TCR-antigenic peptide-MHC complex, TCR-peptide-MHCcomplex).
Principle
There are three main pathways for T cell activation: phosphatidylimosito1 metabolic pathway, protein tyrosine kinase pathway, and T cell activation bypass pathway. In the latter two pathways, there are four main components that play a role in the initial stage of signal transduction. Species ZAP-70 (SykPTK), CD30 complex, Lck/Fyn (SrcPTK) and adaptor protein (1inker for activation of Tcell LAT).
Applications
To study the effects of drugs or therapies on TCR signaling pathways
To study the effect of each virus on TCR signaling pathway
To study the regulation mechanism of TCR signaling pathway in disease
To study the effect of each virus on TCR signaling pathway
To study the regulation mechanism of TCR signaling pathway in disease
Procedure
• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology
Notes
Detectable targets: PI3K, Lck, Zap-70, LAT, Grb2, SOS, PIP3, Digh1, HPK1, ADAP, Plcy1, SLP76, NCK, Vav, Wasp, Ras, CaM, CaMK4, Raf, MEKK1, PKC, PDK1, Akt, CBL2, Bcl10, Mail1, Carma1, TAK1, mTORC1, IKK, MKK7, MKK4, JNK2, p38MAPK, MEK1, MEK2, GADD45-α, JNK, Erk, CREB, NFAT, Fos, Rel, NF-kB, IKB, Jun
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Wide range of applications
For various laboratory needs
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