IL-22 Detection (CAT#: STEM-MB-0289-WXH)

The receptors of IL-22 are IL-10R2 and IL-22R1 respectively. Among them, IL-10R2 is a type II cytokine receptor, which is widely distributed and expressed on almost all cell surfaces. IL-22R1 is also a type II cytokine receptor, mainly distributed in urothelial cells, digestive tract and respiratory tract mucosal cells. IL-10R2 must be combined with IL-22R1 to play a role. After they are combined, they have the ability to mediate IL-22-induced signal transducer and activator of transcription (STAT) activation. The main pathway of IL-22 is the JAK-STAT pathway. IL-22 and IL-22 receptor form IL-22-IL-22R1-IL-10R2 complex to induce phosphorylation and activate tyrosine kinase. The activated tyrosine activating enzyme phosphorylates tyrosine residues on IL-22R1, and then STAT binds to the phosphorylated tyrosine residues. JAK then phosphorylates the IL-22R1-STAT complex.

IL-22 can protect organs or promote disease development, acting on toxic hepatitis, steatohepatitis and T cell-mediated hepatitis, etc.
IL-22 can resist microbial infections,
IL-22 can induce acute inflammatory mediator responses,
IL-22 can enhance natural immunity,
IL-22 can participate in cell proliferation, apoptosis and other processes by affecting important factors in the signal pathway.
IL-22 plays an important role in inflammation.

1. Process samples.
2. IL-22 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types-Blood, serum, plasma, cerebrospinal fluid, cell culture supernatant, tissue homogenate, cell culture medium, urine, tumor, etc.