Sinusitis Animal Model (CAT#: STEM-AE-0082-WXH)

Introduction

Rhinosinusitis (rhinosinusitis) is one of the common and frequently-occurring diseases in clinical otolaryngology. Severe patients will cause their sense of smell disturbance and affect the quality of human life. The pathogenic bacteria of sinusitis are mainly aerobic and anaerobic bacteria such as Streptococcus pneumoniae (40%), Staphylococcus, Haemophilus influenzae. At present, various animal models of rhinosinusitis such as rabbits, rats and mice have been explored and established in related fields, and in-depth research on rhinosinusitis has been carried out using these models.

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Principle Applications Procedure Materials Notes Related Products

Applications

Research on the mechanism and treatment of sinusitis.

Procedure

• Simple nasal inoculation of bacteria: a modeling method in which bacteria are injected directly into the nasal cavity.
• Simple sinus packing.
• Open sinus ostia blockage + nasal cavity inoculation of bacteria: first open the front wall of the maxillary sinus, place blockages from the inside of the sinus to the sinus ostium to block the sinus ostium, and at the same time inoculate the sinus cavity with bacteria.
• Open nasal packing + nasal inoculation bacteria method: open the nasal dorsal bone, and implant the high-expansion sponge soaked in Streptococcus pneumoniae into the nasal cavity.
• Non-open nasal packing + nasal inoculation method: a swollen sponge soaked with Staphylococcus aureus is placed in the nasal cavity of the mouse.

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