Renal Ischemia-reperfusion Animal Model (CAT#: STEM-AE-0074-WXH)

Introduction

Ischemia-reperfusion injury (IRI) is a common problem in organ transplantation, shock, and arterial bypass surgery. The kidney is one of the most common organs where IRI occurs, especially in kidney transplantation, it is inevitable to experience a certain degree of IRI, and renal ischemia-reperfusion injury is a common cause of acute renal failure.

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Principle Applications Procedure Materials Notes Related Products

Applications

• Study on the pathogenic mechanism of renal ischemia-reperfusion in mice.
• Develop anti-inflammatory drugs.

Procedure

1. After the mouse was anesthetized, the abdomen was fixed in the supine position and the midline incision was made.
2. Free the arteriovenous veins of the left kidney and clamp them, and release the clamping after 40-60 minutes. When the left kidney changes from dark red to bright red, it indicates successful renal blood reperfusion.
3. The right renal vein and artery were separated and ligated, and the right kidney was removed.

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