Recombinant Rat EGF Protein, Seafrom (CAT#: STEM-CT-0043-ZJF)

The Recombinant Rat EGF Protein manufactured by Seafrom is suitable for promoting cell growth, proliferation, and differentiation.
The EGFR (Epidermal Growth Factor Receptor) protein is a type I transmembrane glycoprotein and a member of the epidermal growth factor receptor family. It binds to a subset of EGF family ligands, including EGF, amphiregulin, TGF-α, betacellulin, and others. EGFR protein plays a crucial role in signaling pathways that regulate cell proliferation, survival, and differentiation. When a ligand binds to EGFR, it induces homo- or heterodimerization of EGFR protein, followed by tyrosine autophosphorylation and the initiation of various downstream pathways, such as MAPK, PI3K/PKB, and STAT.
Furthermore, EGFR signaling has been associated with carcinogenesis and disease progression. As a result, EGFR protein is currently considered a target for cancer therapy.
The lyophilized product can be stored at 2-8°C for 24 months. For reconstitution, it can be dissolved in injectable water, saline solution, culture medium, or PBS. After dissolution, it should be aliquoted, with a recommended storage period of 6 months at -20°C and 12 months at -80°C. When diluting, ensure a final concentration of no less than 100 μg/mL and avoid repeated freeze-thaw cycles.

Expression Host: HEK293 Cells
Synonyms: Epidermal Growth Factor, Urogastrone, URG
Protein Sequence: DNA sequence encodes mouse EGF (NCBI Reference Sequence: NP_036974) with an Fc tag at the C-terminus
Predicted Molecular Weight: 33.1 kD
Purity: >90%, analyzed by SDS-PAGE
Endotoxin Level: <1 EU/μg
Biological Activity: ED50 determined by BALB/c 3T3 cell proliferation analysis is ≤0.1 ng/mL, corresponding specific activity is ≥1x10^7 IU/mg
Purification Method: Chromatographic purification
Appearance: White loose body

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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