Recombinant Murine TPO Protein, Seafrom (CAT#: STEM-CT-0059-ZJF)

The Recombinant Murine TPO Protein manufactured by Seafrom is suitable for stimulating megakaryocyte and platelet production.
TPO, or Thrombopoietin, is a lineage-specific growth factor produced in the liver, kidneys, and skeletal muscles. It stimulates the proliferation and maturation of megakaryocytes, promoting an increase in the circulating platelet levels in the body. TPO signals through the c-mpl receptor and serves as a crucial regulator of circulating platelets. Both human and mouse TPO exhibit cross-species reactivity.
The lyophilized formulation can be stored at 2-8°C for 24 months. If further dilution is required, it can be reconstituted with injection-grade water, physiological saline, culture medium, or PBS. Once reconstituted, it should be aliquoted, and the aliquots should be stored at -20°C for 6 months or at -80°C for 12 months, with a post-dilution concentration not less than 100 μg/mL, while avoiding repeated freeze-thaw cycles.

Expression Host: HEK293 Cells
Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
Protein Sequence: DNA sequence encodes mouse TPO (NP_033405.1) with a His tag at the C-terminus, contains 180 amino acids, predicted molecular weight of 19.6 kD
Purity: >90%, analyzed by SDS-PAGE
Endotoxin Level: <1 EU/μg
Biological Activity: Assessed by cell proliferation of human leukemia megakaryocytic cell line MO7e, with an effective ED50 of ≤1 ng/mL
Purification Method: Chromatographic purification
Appearance: White loose body

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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