Recombinant Human IL-7 Protein, Seafrom (CAT#: STEM-CT-0019-ZJF)

The Recombinant Human IL-7 Protein manufactured by Seafrom is suitable for promoting T-cell proliferation, activation, and survival.
Interleukin-7 (IL-7) is a crucial cytokine that plays a significant role in the growth, survival, and differentiation of T, B, and NK cells. The heterodimer formed by IL-7 and Hepatocyte Growth Factor (HGF) serves as a growth stimulator for pro-B cell development. Studies involving IL-7 gene knockout in mice have shown the vital role of IL-7 in the survival of lymphoid cells. IL-7 stimulates multipotent progenitor cells to differentiate into lymphoid progenitor cells.
The lyophilized formulation can be stored at 2-8°C for 24 months. For reconstitution, it can be dissolved in injection-grade water, physiological saline, culture medium, or PBS. After dissolution, it should be divided into smaller aliquots and stored at -20°C for 6 months or at -80°C for 12 months, with a final concentration after dilution not lower than 100 μg/mL. Avoid repeated freeze-thaw cycles.

Expression Host: CHO Cells
Synonyms: IL7, Interleukin-7
Protein Sequence: DNA sequence encodes human IL-7 (P13232-1: D26-H177) expressed with an Fc tag at the C-terminus
Molecular Weight: Predicted theoretical molecular weight of 43.8 kD
Purity: >95%, analyzed by SDS-PAGE and HPLC
Endotoxin Level: <0.01 EU/μg
Biological Activity: Cell proliferation assay using PBMC cells activated with CD3 monoclonal antibody, ED50 is 0.5-20 ng/mL, corresponding specific activity is >1x10^7 IU/mg (calibrated against human IL-7 reference standard, NIBSC code: 90/530)
Purification Method: Chromatographic purification
Appearance: White loose body

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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