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IL-23 Detection (CAT#: STEM-MB-0290-WXH)
Introduction
IL-23 is a member of the IL-12 family. It has two subunits, p19 and p40, and it is a heterodimeric molecule. It can be produced by many tissues and cells, such as Th1 cells, macrophages, dendritic cells, etc. IL-23 mainly acts as a pro-inflammatory factor. It mainly acts on memory T cells, having the effect of influencing the immune response and potential anti-tumor and anti-infection effects.
Principle
The receptor of IL-23 is composed of two subunits of IL-12Rβ1 and IL-23R. IL-12Rβ1 mainly binds to the p40 subunit and is mainly expressed on T cells, NK cells and dendritic cells, while IL-23R It mainly binds to the p19 subunit and is only expressed on T cells, NK cells, monocytes and dendritic cells. IL-23 can only conduct signal transduction in the above cells. IL-23 binds to its receptor for signal transduction, activates JAKs, and phosphorylates the STAT binding site in the receptor cell. STAT molecules aggregate in the form of dimers, and then JAKs phosphorylate them. Phosphorylated STAT enters the nucleus and has an effect on gene transcription.
Applications
IL-23 can enhance cellular immunity.
IL-23 has a certain pro-inflammatory effect.
IL-23 is an effective preventive mechanism for bacterial infections.
IL-23 has a certain pro-inflammatory effect.
IL-23 is an effective preventive mechanism for bacterial infections.
Procedure
1. Process samples.
2. IL-23 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.
2. IL-23 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.
Notes
Sample Types-Blood, serum, plasma, cerebrospinal fluid, cell culture supernatant, tissue homogenate, cell culture medium, urine, tumor, etc.
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