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Omentin Signaling Pathway Assay (CAT#: STEM-MB-0369-WXH)
Introduction
Omentin protein is a recently discovered new adipocytokine produced mainly by secretions from visceral adipose tissue. In recent years, it has been found that omentin protein has the functions of enhancing insulin sensitivity, anti-atherosclerosis, reducing inflammatory response, regulating vascular endothelial cell function, and cardiovascular protection, and is closely related to various clinical diseases such as diabetes, cardiovascular diseases, autoimmune diseases, and tumors. Therefore, it is particularly important to study the signaling pathways of omentin protein.
Principle
Omentin has an anti-atherogenic effect. Omentin induces NO synthesis and increases endothelial function by activating AMPK-eNOS phosphorylation. Omentin inhibits a variety of TNF-α-mediated signaling pathways, down-regulates the expression of vascular adhesion molecules, reduces the production of reactive oxygen species, and decreases the infiltration of inflammatory cells into the vessel wall, thus exerting anti-inflammatory and anti-atherosclerotic effects.
Applications
Study the impact of each clinical virus on the omentin signaling pathway
Research on the regulatory mechanism of omentin signaling pathway in medicine
Research on the regulatory mechanism of omentin signaling pathway in medicine
Procedure
• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology
Notes
Detectable targets: RTK, PI3K, TYK2, STAT1, STAT2, STAT3, TNFR, ISGF3, MSK2, PI3K, TBK1, Vav, STAT5, IRAK4, JNK, MYD88, Rac1, TLR4, CREB, IRF3, MAPK, NAP1, Rel, TLR9, MHC-II, IRS1, MEK6, p50, SLP76, TRAM, TCR, icam1, Mda-5, NFκB, RIG-1, TRAF3, GAS, IRF9, MEKK1, p38, RIP1, TRAF5, PSGL1, IRS2, MSK1, TLR3, Tak1, TRIF, CD3, IRF5, MEK3, p38MAPK, SH2, TRAF6, Fas, ISRE, mTOR, PKR
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