Psoriasis Animal Model (CAT#: STEM-AE-0038-WXH)

Introduction

Psoriasis is a skin disorder characterized by epidermal keratinocyte hyperplasia, mediated by cells and molecules of the innate and adaptive immune systems, and is the result of a combination of genetic, epigenetic, and environmental influences. The most commonly used animal model in preclinical research is imiquimod (IMQ)-induced skin injury and skin inflammation model, whose phenotype is similar to human psoriasis. IMQ can cause skin damage in mice, increased rash and desquamation, thickened skin epidermis, and histopathologically seen dermis dominated by parakeratosis and inflammatory leukocyte infiltration.