Study of IgCAMs by Magnetic tweezers (MT) (CAT#: STEM-MB-1261-WXH)

Introduction

Cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) are cell surface glycoproteins highly expressed in the developing and mature nervous system. They are characterized by a large extracellular domain containing one or several immunoglobulin-like (Ig) repeats. Cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) play a crucial role in cell-cell interactions during nervous system development and function.

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Principle Applications Procedure Materials

Principle

Magnetic tweezers (MT) are scientific instruments for the manipulation and characterization of biomolecules or polymers. These apparatus exert forces and torques to individual molecules or groups of molecules. It can be used to measure the tensile strength or the force generated by molecules.

Applications

Study of mechanical properties of biological macromolecules like DNA or proteins in single-molecule experiments.
Study of the rheology of soft matter.
Study of force-regulated processes in living cells.

Procedure

1.Sample preparation
2.Force Calibration
3.Measurement
4.Analysis

Materials

Magnetic tweezers

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