Seplife LXPM CM 5504M Weak Cation-Exchange Medium, ≥105 mg Lysozyme/mL (CAT#: STEM-BC-3103-ZJF)

This weak cation-exchange medium is designed for capture, intermediate purification, and polishing of biological products. It uses a polymethyl methacrylate matrix with a hydrophilic surface modification. Carboxymethyl groups provide weak cation-exchange functionality. The 80 µm particles support high flow with stable bed geometry. A 1000 Å pore size permits biomolecule access through the porous matrix. The high ion-exchange capacity supports a lysozyme loading of at least 105 mg/mL. Strong mechanical properties limit compression during large-scale operation. The medium can be regenerated with sodium chloride and cleaned with sodium hydroxide or ethanol.

Model: Seplife® LXPM CM 5504M
Matrix: Polymethyl methacrylate
Appearance: White opaque spherical particles
Functional group: -O-CH2-COO-
Ion-exchange type: Weak cation exchange
Exchange capacity: 0.26-0.30 mmol/mL
Average particle size: 80 µm
Pore size: 1000 Å
Binding capacity: ≥105 mg lysozyme/mL
Pressure-flow range: 300-1000 cm/h at 22 mm × 20 cm bed and 3 bar
Compression factor: ≤1.05
Maximum pressure: 0.8 MPa
Storage: 20% ethanol solution
Regeneration: 0.5-2 M sodium chloride
Cleaning: 0.1-0.5 M sodium hydroxide or 50% ethanol
Solvent stability: Resistant to acids, alkalis, methanol, ethanol, toluene, DMSO, DMF, and n-heptane

High 0.26-0.30 mmol/mL capacity
≥105 mg/mL lysozyme loading
Weak carboxymethyl exchange
High 300-1000 cm/h flow
Low compression factor
Strong solvent resistance
Hydrophilic particle surface
Suitable for large-scale purification

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