Recombinant Human sTRAIL/Apo2L Protein, Seafrom (CAT#: STEM-CT-0071-ZJF)

The Recombinant Human sTRAIL/Apo2L Protein manufactured by Seafrom is suitable for apoptosis and anti-tumor effects.
TRAIL/Apo2L is a cytotoxic protein capable of inducing rapid apoptosis in tumor cells while having no effect on normal cells. TRAIL-induced apoptosis is achieved by binding to two death signal receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a "death domain" in their cytoplasm, activating the cellular apoptosis machinery. Human sTRAIL/Apo2L is a 281-amino acid protein composed of 17 amino acid cytoplasmic domains, 21 amino acid transmembrane domains, and 243 amino acid extracellular domains.
The lyophilized form can be stored at 4°C for 24 months, while the reconstituted liquid can be stored at -20°C for 6-12 months, avoiding repeated freeze-thaw cycles.

Expression Host: Human HEK293 Cells
Synonyms: CED, DPD1, LAP, TGF-beta1, TGFB, TGFbeta
Protein Sequence: DNA sequence encodes human sTRAIL (NP_003801.1) with an Fc tag at the C-terminus, contains 405 amino acids, predicted molecular weight of 46.3 kD
Purity: ≥95%, analyzed by SDS-PAGE and HPLC
Endotoxin Level: ≤0.01 EU/μg (gel clot method)
Biological Activity: Induction of apoptosis in TRAIL-sensitive U343MG cells with an expected ED50 of 1.0-3.0 ng/mL. Induction of apoptosis in LN-18 cells (human glioblastoma cells) with an expected ED50 of 0.8-2.0 ng/mL
Purification Method: Chromatographic purification

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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