Recombinant Human IL-12B Protein, Seafrom (CAT#: STEM-CT-0076-ZJF)

The Recombinant Human IL-12B Protein manufactured by Seafrom is suitable for immune response regulation and cell differentiation.
IL-12, also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a pleiotropic cytokine originally identified in human mature B-lymphoblastoid cells. The p40 subunit of IL-12 has been found to share extensive homologous amino acid sequences with the extracellular region of the human IL-6 receptor. Interleukin-12 Subunit Beta (IL12B), also known as NKSF2, CLMF2, and P40, interacts with IL-23.
Cells that produce IL-12 also secrete significant amounts of monomeric IL12B, which does not exhibit apparent biological activity. Overexpression of the IL12B gene is associated with the pathogenesis of multiple sclerosis. Furthermore, research suggests that polymorphisms in the gene's promoter region are related to the severity of childhood atopic and non-atopic asthma.
The lyophilized form can be stored at 4°C for 24 months, and the reconstituted liquid can be stored at -20°C for 6-12 months, while avoiding repeated freeze-thaw cycles.

Expression Host: Human HEK293 Cells
Synonyms: IL12B, CLMF, CLMF2, NKSF, NKSF2, p40
Protein Sequence: DNA sequence encodes human IL-12B (NP_002178.2) with a His tag at the C-terminus, contains 319 amino acids, predicted molecular weight of 36.4 kD
Purity: ≥95%, analyzed by SDS-PAGE and HPLC
Endotoxin Level: <0.1 EU/μg (gel clot method)
Biological Activity: Binding to human IL-12B (His-tag) in a linear range of 0.2-20 ng/mL with a fixed anti-IL-12B antibody at 5 μg/mL (100 μL/well)
Purification Method: Chromatographic purification

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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