Recombinant Human IL-1β Protein, Seafrom (CAT#: STEM-CT-0011-ZJF)

The Recombinant Human IL-1β Protein manufactured by Seafrom is suitable for studying pro-inflammatory effects and signaling pathways.
IL-1β is a pro-inflammatory cytokine produced in various cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. IL-1α and IL-1β bind to the same receptor and exhibit similar biological properties. These cytokines have a wide range of activities, including promoting thymocyte proliferation, B cell maturation and proliferation by inducing IL-2 release, fibroblast growth factor-like activity, synovial cell release of prostaglandins, and collagenase, among others. However, IL-1β is a secreted cytokine, while IL-1α is primarily a cell-associated cytokine.
Lyophilized preparations can be stored at 2~8°C for 24 months. For aliquoting, they can be reconstituted with injection water, physiological saline, culture medium, or PBS. After reconstitution, divide into smaller portions and store at -20°C for 6 months or at -80°C for 12 months. The final concentration after dilution should not be lower than 100μg/mL. Avoid repeated freeze-thaw cycles.

Expression Host: HEK293 Cells
Synonyms: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL1B, IL-1BETA, IL1F2, IL-1β
Protein Sequence: DNA sequence encodes human IL-1β (GenBank: AAA72849.1) expressed with a C-terminal His tag
Molecular Weight: Recombinant human IL-1β protein consists of 159 amino acids with a predicted molecular weight of 18.2 kD
Purity: >90%, analyzed by SDS-PAGE
Endotoxin Level: <0.1 EU/μg
Biological Activity: Cell proliferation assay using D10 cells, ED50≤0.1 ng/mL
Purification Method: Chromatographic purification
Appearance: White loose body

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

Anti-Human PD-1 mAb, Seafrom
Humanized Anti-Human CD3/CD19 Bispecific Antibody, Seafrom
Recombinant Human IL-1α Protein, Seafrom
Recombinant Human IL-2 Protein, Seafrom