NMCHT Type II Chromatographic Media, 1 KG (CAT#: STEM-C-3855-ZJF)

Ceramic hydroxyapatite (CHT) is a hydroxyapatite-based composite material with significant value as a chromatographic medium. Featuring a spherical structure with macropores, CHT stands out as a mixed-mode resin combining metal affinity and cation exchange functionalities. This unique selectivity enables effective and versatile purification solutions. CHT is particularly suitable for purifying a wide range of biomacromolecules, including antibodies, viral particles, vaccines, recombinant proteins, and nucleic acids.
Two types of CHT are available to meet specific purification needs. Type I provides a higher binding capacity, making it ideal for purifying small proteins. Type II features larger pores, specifically designed to efficiently purify larger macromolecules such as viruses, IgM, virus-like particles (VLPs), and plasmids. These tailored options offer reliable performance across diverse bioprocessing applications.

Functional group: Ca²⁺, PO₄³⁻, -OH
Particle size: 40±4 μm
Tap-settled density: 0.72 g/mL
DBC (IgG): ~15 mg/mL
Recommended flow rate: 50-1000 cm/h
Sanitization: 1-2 M NaOH
pH stability: 6.5-14, at least 1 year in 1 M NaOH
Regeneration: 0.4 M sodium phosphate buffer, pH 7-7.5; 1 M trisodium phosphate, pH 11-12; 0.4-1 M potassium phosphate buffer
Autoclavability: 121 ℃, 20 min, phosphate buffer, pH 7
Storage: 0.1 M NaOH, room temperature

Mixed-Mode Chromatography Media: Ceramic Hydroxyapatite (CHT) offers both metal affinity and cation ion exchange capabilities for unique selectivity.
Versatile Purification: Suitable for the purification of a wide range of biomacromolecules, including antibodies, virus particles, vaccines, recombinant proteins, and nucleic acids.
Spherical Appearance with Macropores: The spherical shape and macropores of CHT provide excellent flow properties and efficient separation.
NMCHT Type I: Higher binding capacity, ideal for small protein purification.
NMCHT Type II: Larger pore size, optimized for the purification of macromolecules such as viruses, IgM, VLP particles, and plasmids.
Effective Purification Solutions: Offers unique and effective purification solutions with high selectivity, suitable for diverse biopharmaceutical applications.

STEM-C-3853-ZJF
STEM-C-3854-ZJF
STEM-C-3856-ZJF
STEM-L-0455-ZJF