Mouse & Rat Breeding Service (CAT#: STEM-AE-0102-WXH)

Introduction

The ability to interrogate the entire coding sequence of the mouse combined with the tools to manipulate the genome has firmly established the mouse as the model organism of choice for studying the causes of human disease. Consequently, a huge number of novel mouse models are generated each year to support active research programs. However, it is neither ethically justifiable, nor economically viable to maintain mouse colonies on the shelf that are not part of active research programs. This means that novel mouse lines have to be preserved in some way. If this is not done and the line is simply killed off, the genetics will be lost to future generations of scientists. So the conservation of mouse models is necessary.<br />The current preservation methods include freezing of genetic material and preservation of a small amount of live species, which can guarantee the preservation of strains at the lowest cost, and can quickly restore the breeding scale required by the experiment.<br />Compared with the basic strain mice, the mouse models created by genetic engineering technology have differences in physiological homeostasis, metabolism, and behavioral patterns, so they have special requirements in terms of feeding conditions.