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Conditional gene knockout mice: The deletion of the target gene occurs only in a certain stage of the mouse life cycle or in a specific tissue, while the expression is normal in other tissues or cells. Thus, the scope and timing of the modification of the mouse genome are in a controllable state.
Compared with conventional gene knockout, the advantage of conditional gene knockout is that it can prevent embryonic lethality and complete gene knockout at a specific time in a specific tissue.
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