IL-34 Detection (CAT#: STEM-MB-0300-WXH)

The receptor for IL-34 is colony-stimulating factor-1 receptor (CSF-1R), which is a tyrosine kinase receptor encoded by the proto-oncogene c-fms. CSF-1R can be produced in monocytes, fibroblasts, endothelial cells and tumor cells. IL-34 is the second functional ligand of CSF-1R. After dimerization, IL-34 can bind to CSF-1R, mediate intracellular signal transduction, and participate in cell proliferation, differentiation, apoptosis and various biological activities. The combination of IL-34 and CSF-1R phosphorylates extracellular signal-regulated kinase (ERK)-1 and ERK-2.

IL-34 has the ability of immune regulation and can promote inflammation.
IL-34 can stimulate the growth, proliferation and differentiation of monocytes into macrophages, and promote the survival, proliferation and differentiation of osteoclasts as well as bone marrow cells.

1. Process samples.
2. IL-34 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types-Blood, serum, plasma, cerebrospinal fluid, cell culture supernatant, tissue homogenate, cell culture medium, urine, tumor, etc.