High-Throughput Drug Screening

Efficient screening of pharmaceutically valuable lead compounds is critical for the drug discovery process. Traditional high-throughput screening technologies involve robotics for automatic liquid and plate handling. But these instruments are usually associated with high cost, which restricts many researchers from performing high-throughput drug screening independently. As a result, there is a strong desire to develop low-cost technologies that require reduced sample and reagent consumption. The development of microfluidic techniques provides a possibility to realize low-cost, high-throughput screening and validation of potential drug candidates. In addition, compared to the conventional cell assay systems, microfluidic-based drug screening platform has the potential for integration and the ability to reconstitute the cell microenvironment at the microscale.

What We Can Do for You

STEMart can utilize a variety of microfluidics technologies to help customers achieve high-throughput drug screening:

• Droplet microfluidics: Droplet microfluidics allows for generation and manipulation of thousands to millions of droplets containing cells, enzymes, or small molecules. With droplet microfluidics, STEMart provides:
  • High-throughput screening of potential drug candidates or compounds for their efficacy, toxicity, or other properties
  • Study of drug stability, drug release kinetic, drug solubility, drug bioavailability, and optimization of drug delivery systems and formulations and for improved therapeutic properties
  • Study of biomolecular interactions such as protein-protein interactions, enzyme kinetics, or DNA-protein binding, aiding in understanding the mechanisms of drug action
• Microfluidics-based single cell analysis: Microfluidics-based single cell analysis allows precise manipulation of individual cells in a controlled environment for analysis of genomics, transcriptomics, proteomics, and metabolomics at the single-cell level. With microfluidics-based single cell analysis, STEMart provides:
  • Analysis of cell response to drug treatment via gene expression, protein level, and metabolic activity of single cells
  • Development of personalized medicine approaches by analyzing the response of individual cells to different drug compounds
  • Identification of drug resistance mechanisms by analyzing the response of individual cells to different drug compounds
• Microfluidics-based 3D cellular model: Microfluidic-based 3D cellular model mimic spatial cell-cell, cell-extracellular matrix interactions present in vivo. With Microfluidics-based 3D cellular model, STEMart provides:
  • Identification of drug resistance mechanisms
  • Evaluation of anticancer drug activity
• Organ-on-a-chip: Integrate multiple cell types and tissues to create organ-on-a-chip models that replicate the structure and function of organs in the human body. With organ-on-a-chip, STEMart provides:
  • Identification of drug mechanisms
  • Evaluation of drug toxicity and efficacy

For more information about our high-throughput drug screening service, please contact us.