Determination of Melting Point of the Binary Systems of Fenofibrate and Dense Gases by Capillary Method (CAT#: STEM-PPA-0042-YJL)

Introduction

Fenofibrate is a fibrate lipid regulating agent used for the treatment of hypertriglyceridemia and hypercholesterolemia. It reduces high plasma concentration of triglycerides and cholesterol to a normal level. Fenofibrate a BCS (The Biopharmaceutical Classification System) class II drug is characterized by a good permeability but a low oral bioavailability due to the poor solubility in an aqueous environment. Modification of the delivery system presents a promising solution to improve dissolution behavior of such poorly soluble drugs.

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Principle Applications Procedure Materials Notes Related Products

Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
The melting point measurement is usually performed in thin glass capillary tubes with an internal diameter of 1 mm and a wall thickness of 0.1 – 0.2 mm. A finely-ground sample is placed in the capillary tube to a filling level of 2 – 3 mm and introduced in a heated stand (liquid bath or metal block) in close proximity to a high accuracy thermometer. The temperature in the heating stand is ramped at a user-programmable fixed rate. The melting process is visually inspected to determine the melting point of the sample.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Seal capillary.
2. Fill the sample.
3. Install the instrument.
4. Determine the melting point.

Materials

• Sample Type: crystalline compounds

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