Determination of Melting Point of Itraconazole by Capillary Method (CAT#: STEM-PPA-0057-YJL)

Introduction

Itraconazole is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. It may be given by mouth or intravenously. Common side effects include nausea, diarrhea, abdominal pain, rash, and headache. Severe side effects may include liver problems, heart failure, Stevens-Johnson syndrome and allergic reactions including anaphylaxis. <br />Pre-formulation study is an essential part of development process. These studies focus on physicochemical propertyof drug could affect its performance and development of dosage form. These studies are indispensable protocol for development of safe,effective and stable dosage form. The drug sample was identified by various techniques such as IR Spectroscopy, UV Spectroscopy, melting point, partition coefficient for novel formulation.