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Determination of Melting Point of New Substances among 2-(1,2,4-triazoles-3-ylthio)-1-aryletanone by Open Capillary Method (CAT#: STEM-PPA-0069-YJL)
Introduction
Searching of the biologically active substances among heterocyclic nitrogen containing compounds causes a considerable interest and attention of many researchers. Because an amount of highly efficient drugs always supplements with derivatives of such heterocyclic systems. Derivatives of 1,2,4-triazoles are characterized by a number of valuable properties, namely low toxicity, reactionary ability, expressed biological activity. Therefore, the combination of this kind of molecule with various sintons is an actual task for modern pharmacy and medicine. It is of great significance to study the physical, chemical and biological properties of new substances among 2- (1,2,4-triazoles-3-ylthio)-1-aryletanone.
Principle
Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
Applications
Chemical industry; Cosmetic/pharmaceutical industry
Procedure
1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
Materials
• Sample Type: crystalline compounds
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