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Bone Defect Animal Model (CAT#: STEM-AE-0019-WXH)

Introduction

Bone defect is a difficult problem in orthopedic clinical work. At present, the conventional ways of repairing bone defects are autologous bone grafting and allogeneic bone grafting, but both have certain disadvantages. Autologous bone grafts cause damage to the donor site and bring additional burdens to patients: allogeneic bone grafts have the risk of spreading diseases and have rejection reactions. Moreover, for large-scale bone defects, both of them have the problem of limited source of bone mass. In recent years, the research on various bone tissue replacement materials has been increasing, and the establishment of bone defect models is the basis of these researches.




Applications

Study the effect of bone substitutes, biologics or cell products on bone regeneration.

Procedure

Take the construction of a rabbit radial bone defect model as an example:
1. Weigh and anesthetize.
2. After the rabbit is anesthetized, the forelimbs are cut and the skin is prepared, the rabbit is fixed in the prone position, and the drape is spread and then disinfected.
3. Bluntly dissect the radial muscle space to expose the radius.
4. Excision of a large segment of bone in the radius using an electric drill.
5. Suturing the Surgical Incision.

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