Analysis of Elastase-2 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0139-LGZ)

Introduction

Elastase 2 is a chymotrypsin family serine protease that plays an important role in pathogen clearance. It is expressed by promyelocytes and stored in intracellular azurophilic granules of polymorphonuclear leukocytes. ELA2 can degrade a variety of extracellular matrix proteins, including elastin and fibronectin. Multiple mutations in the ELA2 gene cause severe congenital and cyclic neutropenia.