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SNP Genotyping (CAT#: STEM-MB-0055-WXH)
Introduction
SNP genotyping is the measurement of genetic variations of single nucleotide polymorphisms (SNPs) between members of a species. It is a form of genotyping, which is the measurement of more general genetic variation. SNPs are one of the most common types of genetic variation. An SNP is a single base pair mutation at a specific locus, usually consisting of two alleles (where the rare allele frequency is > 1%). SNPs are found to be involved in the etiology of many human diseases and are becoming of particular interest in pharmacogenetics.
Applications
• Analysis of susceptibility genes and gene localization for complex diseases.
• Detection of environmental factor susceptibility genes and genetic analysis of pathogens.
• Drug development and individual drug use.
• Individual identification and forensic identification.
• Phylogenetic analysis and elucidation of molecular genetic mechanisms of pathology.
• Biological evolution and genetic analysis.
• Detection of environmental factor susceptibility genes and genetic analysis of pathogens.
• Drug development and individual drug use.
• Individual identification and forensic identification.
• Phylogenetic analysis and elucidation of molecular genetic mechanisms of pathology.
• Biological evolution and genetic analysis.
Procedure
Main methods of SNP analysis.
1.Traditional classical detection methods based on gel electrophoresis: such as restriction fragment length polymorphism (PCR-RFLP), single-strand conformation polymorphism (PCR-SSCP), denaturing gradient gel eletrophoresis (DGGE), allelespecific PCR ( allelespecific PCR (ASPCR), etc. These methods are relatively obsolete, and customers are recommended to combine with other methods for detection.
2.High-throughput and highly automated detection methods developed in recent years: such as DNA sequencing, DNA microarray, mass spectrometry (MassARRAy), denaturing high performance liquid chromatography (DHPLC), SNaPshot, probe, HRM, Illumina BeadXpress, etc.
1.Traditional classical detection methods based on gel electrophoresis: such as restriction fragment length polymorphism (PCR-RFLP), single-strand conformation polymorphism (PCR-SSCP), denaturing gradient gel eletrophoresis (DGGE), allelespecific PCR ( allelespecific PCR (ASPCR), etc. These methods are relatively obsolete, and customers are recommended to combine with other methods for detection.
2.High-throughput and highly automated detection methods developed in recent years: such as DNA sequencing, DNA microarray, mass spectrometry (MassARRAy), denaturing high performance liquid chromatography (DHPLC), SNaPshot, probe, HRM, Illumina BeadXpress, etc.
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Wide range of applications
For various laboratory needs
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