MA Large Scale HP Multimodal Medium, 45-85 mg mAb/mL (CAT#: STEM-BC-3153-ZJF)

This multimodal chromatography medium is designed for intermediate and polishing purification of monoclonal antibodies. It uses high-flow agarose microspheres as the supporting matrix. The medium combines strong anion-exchange, hydrophobic, and hydrogen-bonding interactions. These mechanisms enable simultaneous removal of several process-related impurities. The resin can reduce aggregates, residual Protein A, host-cell proteins, nucleic acids, and viruses. A dynamic monoclonal-antibody capacity of 45-85 mg/mL supports productive processing. The particles operate at the stated flow and pressure while maintaining stable bed performance. Broad short-term pH tolerance supports cleaning-in-place procedures. The medium can shorten downstream workflows by combining multiple impurity-removal functions in one step.

Model: MA Large Scale HP
Appearance: White spherical gel, odorless and tasteless
Matrix: Large Scale HP microspheres
Chromatography mode: Multimodal strong anion exchange
Interaction mechanisms: Anion exchange, hydrophobic interaction, and hydrogen bonding
Particle size: 45-165 µm
Dynamic monoclonal-antibody capacity: 45-85 mg/mL
Flow performance: 220 cm/h at 0.3 MPa
Long-term pH stability: 3-12
Short-term CIP pH stability: 2-14
Chemical compatibility: Common aqueous solutions, 1 M sodium hydroxide, and 1 M acetic acid
Target impurities: Aggregates, DNA, host-cell proteins, residual Protein A, and viruses

Multimodal antibody polishing
Removes multiple impurity classes
45-85 mg/mL dynamic capacity
Strong anion-exchange functionality
High-flow agarose matrix
Broad CIP pH range
Supports process-cycle reduction
Suitable for intermediate and fine purification

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