Investigation of Extracellular transport of NPs (nanoparticles) by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0748-WXH)

Name: Investigation of Extracellular transport of NPs (nanoparticles) by Nanoparticle tracking analysis (NTA)
SKU: STEM-MB-0748-WXH
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Introduction

The effective transport of NPs through extracellular barriers, such as mucus and interstitium, may be critically important in order to achieve the desired therapeutic and/or diagnostic goals.
Particle tracking can be an invaluable tool to probe the quantitative transport properties of engineered nanomaterials as they move through these complex barriers. Information gathered from particle-tracking experiments can feedback into the design process to improve NP p hysicochemical properties and reach design aims.

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Principle Applications Procedure Materials

Principle

Nanoparticle tracking analysis (NTA) is a method for visualizing and analyzing particles in liquids that relates the rate of Brownian motion to particle size. The rate of movement is related only to the viscosity and temperature of the liquid; it is not influenced by particle density or refractive index. NTA allows the determination of a size distribution profile of small particles with a diameter of approximately 10-1000 nanometers (nm) in liquid suspension.

Applications

NTA has been used by commercial, academic, and government laboratories working with nanoparticle toxicology, drug delivery, exosomes, microvesicles, bacterial membrane vesicles, and other small biological particles, virology and vaccine production, ecotoxicology, protein aggregation, orthopedic implants, inks and pigments, and nanobubbles.