In Vivo Pharmacodynamic Evaluation of Papain Induced Pneumonia Mouse Model (CAT#: STEM-AE-0684-LGZ)

Introduction

Acute lung inflammation usually occurs with asthma. Alternaria and papain are allergens disrupting the airway epithelium triggering a rapid inflammation with eosinophils mediated by innate lymphoid cell activation. Intranasal administration of alternaria or papain to mice are able to induces a rapid influx of neutrophils into the lungs, so as to produce lung inflammation.