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In Vivo Pharmacodynamic Evaluation of G361 Cell Line Based Melanoma (CAT#: STEM-AE-0091-LGZ)
Introduction
Melanoma is one of the more common and important cancers, and its incidence continues to increase. Prognosis for patients with advanced melanoma varies from country to country, but early diagnosis can significantly reduce mortality. Sun exposure is a major risk factor for melanoma, and it has been confirmed that different genetic changes are associated with melanoma. Examples include germline mutations in CDKN2A, mutations in mitogen-activated protein kinase cascade pathways, BRAF and NRAS mutations, KIT mutations, GNAQ and GNA11 mutations.
Principle
In vivo activity is the gold standard for the evaluation of drug biological activity, and it is the first verification of non-human comprehensive activity. In vivo pharmacodynamic evaluation plays a decisive role in the confirmation of candidate molecules and the screening of clinical target indications, and is an indispensable link in the development of new drugs. We provide a variety of disease animal models including inflammation, immunity, metabolism, etc., to meet the needs of different new drug research and development projects of customers, and accept customized services.
In vivo pharmacodynamic evaluation, as the basic research of new drugs, is carried out on animals. It is to verify the effect of drugs with the comprehensive participation of a number of other factors, and to understand the effect of drugs on a certain part of the body by comparing and analyzing the animal signs, in vitro organs, blood components, histone expression and tissue changes before and after drug administration.
In vivo pharmacodynamic evaluation, as the basic research of new drugs, is carried out on animals. It is to verify the effect of drugs with the comprehensive participation of a number of other factors, and to understand the effect of drugs on a certain part of the body by comparing and analyzing the animal signs, in vitro organs, blood components, histone expression and tissue changes before and after drug administration.
Applications
Melanoma
Procedure
1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.
Materials
• Sample Type: liquid or powder
Notes
Oncology efficacy Service package:
In vivo syngeneic model
In vivo CDX model
In vivo PBMC humanized model
In vivo transgenic mouse model
In vivo orthotropic or Metastasis tumor model
In vivo syngeneic model
In vivo CDX model
In vivo PBMC humanized model
In vivo transgenic mouse model
In vivo orthotropic or Metastasis tumor model
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