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In Vivo Pharmacodynamic Evaluation of CAL27 Cell Line Based Pancreas Cancer (CAT#: STEM-AE-0103-LGZ)
Introduction
Pancreatic cancer is one of the most common malignant tumors of digestive tract. Abdominal pain and painless jaundice are common symptoms of pancreatic head cancer. The functions of the pancreas include exocrine and endocrine functions. Pancreatic tissue can produce pancreatic fluid for exocrine function, its exocrine main component is pancreatic fluid, containing alkaline bicarbonate and a variety of digestive enzymes, its function is to neutralize stomach acid, digest sugar, protein and fat; The main endocrine components of pancreatic islet cells are insulin and glucagon, followed by growth hormone releasing inhibitory hormone, intestinal vasoactive peptide, gastrin and other substances belonging to endocrine function.
Principle
In vivo activity is the gold standard for the evaluation of drug biological activity, and it is the first verification of non-human comprehensive activity. In vivo pharmacodynamic evaluation plays a decisive role in the confirmation of candidate molecules and the screening of clinical target indications, and is an indispensable link in the development of new drugs. We provide a variety of disease animal models including inflammation, immunity, metabolism, etc., to meet the needs of different new drug research and development projects of customers, and accept customized services.
In vivo pharmacodynamic evaluation, as the basic research of new drugs, is carried out on animals. It is to verify the effect of drugs with the comprehensive participation of a number of other factors, and to understand the effect of drugs on a certain part of the body by comparing and analyzing the animal signs, in vitro organs, blood components, histone expression and tissue changes before and after drug administration.
In vivo pharmacodynamic evaluation, as the basic research of new drugs, is carried out on animals. It is to verify the effect of drugs with the comprehensive participation of a number of other factors, and to understand the effect of drugs on a certain part of the body by comparing and analyzing the animal signs, in vitro organs, blood components, histone expression and tissue changes before and after drug administration.
Applications
Pancreas Cancer
Procedure
1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.
Materials
• Sample Type: liquid or powder
Notes
Oncology efficacy Service package:
In vivo syngeneic model
In vivo CDX model
In vivo PBMC humanized model
In vivo transgenic mouse model
In vivo orthotropic or Metastasis tumor model
In vivo syngeneic model
In vivo CDX model
In vivo PBMC humanized model
In vivo transgenic mouse model
In vivo orthotropic or Metastasis tumor model
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