CM Seplife C25 Weak Cation-Exchange Medium, 190 mg Ribonuclease/mL (CAT#: STEM-BC-3174-ZJF)

This weak cation-exchange medium is designed for separation of proteins, peptides, nucleotides, and selected macromolecules. It uses highly crosslinked dextran G25 as the supporting matrix. Carboxymethyl groups provide weak cation-exchange functionality. The dry particles range from 40 to 120 µm. A ribonuclease adsorption capacity of 190 mg/mL supports high-productivity purification. The medium provides flow above 200 cm/h with relatively low backpressure. Its high ion-exchange capacity supports preparative processing. The matrix is stable in common aqueous buffers and concentrated denaturants. It also tolerates the stated steam-treatment conditions in sodium chloride solution.

Model: CM Seplife C25
Appearance: White particles, odorless and tasteless
Type: Weak cation-exchange medium
Matrix: Dextran G25
Ligand: Carboxymethyl
Dry particle size: 40-120 µm
Maximum flow rate:>200 cm/h
Ribonuclease adsorption capacity: 190 mg/mL
Ion-exchange capacity: 4.0-5.0 mmol/g dry gel
Long-term pH stability: 2-13
Short-term pH stability: 2-13
Chemical compatibility: Common aqueous buffers, 8 M urea, and 6 M guanidine hydrochloride
Heat resistance: 121°C in 0.1 M sodium chloride for 30 min
Stated separation application: Proteins, peptides, nucleotides, and species above 30000 molecular weight

Very high ribonuclease capacity
Weak carboxymethyl exchange
More than 200 cm/h flow
High ion-exchange capacity
Crosslinked dextran matrix
Broad pH stability
Denaturant compatibility
Steam-treatment tolerance

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