The AutoOligo2000 is a pilot quality manufacturing standard nucleic acid synthesizer for automated solid-phase oligonucleotide synthesis. It is designed for 10-150 mmol clinical sample and oligonucleotide drug production. A high-precision diaphragm pump drive system supports controlled reagent delivery at production scale. The flow-through solid-phase synthesis design supports efficient reagent contact with the synthesis column. The instrument provides real-time monitoring across the synthesis process. Its 316L stainless steel wetted flow path is suitable for robust manufacturing workflows. The system supports quality manufacturing standard-related quality documentation and validation services. It is appropriate for process development and clinical-scale oligonucleotide manufacturing.
10-150 mmol oligonucleotide synthesis High automation level Real-time synthesis process monitoring quality manufacturing standard documentation support Validation service support regulatory compliance 21 CFR Part 11 software support Stable system architecture Industrial component configuration