Analysis of LIMS1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1465-LGZ)

Introduction

Official Full Name: LIM zinc finger domain containing 1
Also known as: PINCH; PINCH1; PINCH-1
The protein encoded by this gene is an adapter protein containing 5 LIM domains or double zinc fingers. This protein may be involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinases found in focal adhesion plaques. It is also considered to be a bridge between integrin-linked kinase and NCK adapter protein 2, which is involved in the growth factor receptor kinase signaling pathway. Its localization around spreading cells also suggests that the protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants of this gene have been found encoding different isoforms.