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Cerebral concussion Animal Model (CAT#: STEM-AE-0049-WXH)

Introduction

Cerebral concussion (CC) is a mild brain injury. Post-concussion syndrome (PCS) is a common sequela of brain injury. Among its various clinical manifestations, changes in cognition, learning and memory are one of the most common impairment manifestations.




Applications

• Research on the pathogenesis and treatment of concussions.
• Drug development, drug screening and efficacy research.

Procedure

1. Before striking, record the breathing rate of the rat per minute, test the corneal reflex, pain reflex, external auditory canal stimulation response, and righting reflex of the rat, and record the rat's psychomotor situation, whether there is vertical tail, incontinence, etc..
2. Fix the fully awake rats on the metal single pendulum type closed brain injury model replicator test bench, raise the head 45°, lift the pendulum up to an angle of 95°-105°, the pendulum falls freely, hits On the top of the forehead of the rat. Record the respiratory rate of the rats 1 min, 3 min, 5 min, 10 min and 30 min after the impact, respectively, and test the above-mentioned various reflexes or reactions.

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